Enhanced basal nitric oxide production in heart failure: another failed counter-regulatory vasodilator mechanism?

Autor:	C. M. Oakley, F. M. Habib, David C. Crossman, John G.F. Cleland, David P. Dutka
Rok vydání:	1994
Předmět:	Male medicine.medical_specialty Heart disease Cardiac Output Low Endogeny Vasodilation Arginine Nitric Oxide Nitric oxide Basal (phylogenetics) chemistry.chemical_compound Internal medicine medicine Humans Endothelial dysfunction Aged Heart Failure omega-N-Methylarginine business.industry Hemodynamics General Medicine Middle Aged medicine.disease Increased vascular resistance Endocrinology chemistry Heart failure Heart Function Tests cardiovascular system Female business
Zdroj:	Lancet (London, England). 344(8919)
ISSN:	0140-6736
Popis:	Endothelial dysfunction in heart failure could impair nitric oxide production and lead to increased vascular resistance. If endogenous production of nitric oxide is reduced, NG-monomethyl-L-arginine (L-NMMA), an inhibitor of such production, should have a diminished vasoconstrictor effect. We administered L-NMMA to 12 patients being investigated for heart failure. L-NMMA increased median pulmonary and systemic vascular resistances by 61 (range -3 to 240) and 430 (63 to 1609) dynes s cm-5, respectively (p0.03 and p0.005). Arterial pressures also increased. Median cardiac output fell by 0.6 (0 to -2.3) L per min (p0.005). These data suggest that vascular nitric oxide may be another example of a failed counter-regulatory vasodilator system in heart failure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248968f939f8398178fd44161a0bb229 https://pubmed.ncbi.nlm.nih.gov/7993474 Zobrazit plný text záznamu Plný text ve formátu HTML
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