Physiological Society of Japan

Autor: Minoru Okita, Yohei Hamaue, Jyunya Sakamoto, Toshiro Yoshimura, Sayaka Chuganji, Jiro Nakano, Y. Sekino, Tomoki Origuchi
Rok vydání: 2013
Předmět:
Zdroj: The Journal of Physiological Sciences. 63:401-408
ISSN: 1880-6562
1880-6546
DOI: 10.1007/s12576-013-0277-4
Popis: This study examined mechanical and thermal hypersensitivity in the rat hind paw during cast immobilization of the hind limbs for 4 or 8 weeks and following cast removal. Blood flow, skin temperature, and volume of the rat hind paw were assessed in order to determine peripheral circulation of the hind limbs. Sensitization was analyzed by measuring the expression of the calcitonin gene-related peptide (CGRP) in the spinal dorsal horn following cast immobilization. Two weeks post immobilization, mechanical and thermal sensitivities increased significantly in all rats; however, peripheral circulation was not affected by immobilization. Cast immobilization for 8 weeks induced more serious hypersensitivity compared to cast immobilization for 4 weeks. Moreover, CGRP expression in the deeper lamina layer of the spinal dorsal horn increased in the rats immobilized for 8 weeks but not in those immobilized for 4 weeks. These findings suggest that immobilization-induced hypersensitivity develops during the immobilization period without affecting peripheral circulation. Our results also highlight the possibility that prolonged immobilization induces central sensitization in the spinal cord.
The final publication is available at link.springer.com
The Journal of Physiological Sciences, 63(6), pp.401-408; 2013
Databáze: OpenAIRE
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