The brainstem respiratory network: an overview of a half century of research
| Autor: | Christian Gestreau, Armand L. Bianchi |
|---|---|
| Přispěvatelé: | Science et Ingénierie des Matériaux et Procédés (SIMaP), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Pulmonary and Respiratory Medicine
Physiology Action Potentials Network reconfiguration Biology History 21st Century Models Biological 03 medical and health sciences 0302 clinical medicine Animals Humans Respiratory system [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] 030304 developmental biology Neurons 0303 health sciences Respiratory Physiological Phenomena General Neuroscience Research Central pattern generator Complex network History 20th Century Respiratory Center Electric Stimulation Respiratory network Synapses Brainstem Nerve Net Neuroscience 030217 neurology & neurosurgery Brain Stem |
| Zdroj: | Respiratory Physiology and Neurobiology Respiratory Physiology and Neurobiology, Elsevier, 2009, 168 (1-2), pp.4-12. ⟨10.1016/j.resp.2009.04.019⟩ Respiratory Physiology & Neurobiology Respiratory Physiology & Neurobiology, 2009, 168 (1-2), pp.4-12. ⟨10.1016/j.resp.2009.04.019⟩ |
| ISSN: | 1569-9048 1878-1519 |
| DOI: | 10.1016/j.resp.2009.04.019⟩ |
| Popis: | International audience; This review aims at summarizing the work performed over 40 years by Professor Armand Bianchi and the research team he directed, which was devoted to the study of the central respiratory network. The major steps towards the understanding of this complex network will be presented together with methodological considerations. This includes the sequential progress that was made in the identification and characterization of respiratory neurons as deduced from inferences gleaned from intracellular recordings, which revealed putative synaptic connections within the respiratory network. Also reviewed is a comparison of in vivo versus in vitro approaches. The search for the "real" respiratory neurons must consider that those neurons are redundantly represented within the brainstem and express a wide variety of patterns. The last part of this review focuses on the concept that the brainstem respiratory circuitry forms part of a multifunctional network subserving both respiration and non-respiratory motor behaviors. Numerous data provide evidence that the respiratory network operates as a dynamic assembly of neurons, some of which can belong to several networks involved in the coordination of respiratory muscles during functions that include coughing, swallowing and vomiting. |
| Databáze: | OpenAIRE |
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