Differential impacts of postoperative complications on patients’ survival in completely resected non-small-cell lung cancer
Autor: | Takayuki Fukui, Tomoshi Sugiyama, Yuka Kadomatsu, Harushi Ueno, Hideki Tsubouchi, Toyofumi F. Chen-Yoshikawa, Naoki Ozeki, Keita Nakanishi, Shota Nakamura, Masaki Goto |
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Rok vydání: | 2021 |
Předmět: |
Pulmonary and Respiratory Medicine
Pulmonary Atelectasis medicine.medical_specialty Lung Neoplasms Atelectasis Gastroenterology Postoperative Complications Carcinoma Non-Small-Cell Lung Internal medicine medicine Humans Lung cancer Proportional Hazards Models Retrospective Studies business.industry Proportional hazards model Hazard ratio General Medicine medicine.disease Confidence interval Pneumonia Acute Interstitial Pneumonia Surgery Neoplasm Recurrence Local Cardiology and Cardiovascular Medicine business Complication |
Zdroj: | General Thoracic and Cardiovascular Surgery. 69:1283-1290 |
ISSN: | 1863-6713 1863-6705 |
Popis: | The aim of this study was to investigate the effects of inflammatory respiratory complications on long-term survival in patients with resected non-small cell lung cancer. We defined inflammatory respiratory complications to include the following six conditions: pneumonia, empyema, bronchial fistula, respiratory dysfunction, acute interstitial pneumonia, and atelectasis. Part of the National Clinical Database was linked to our prospective database from 2014 to 2017. Linkage was achieved for 866 patients. The Kaplan–Meier method was used to evaluate the overall, relapse-free, and cancer-related survival. The Cox proportional hazard model was used to analyze the impact of each complication. Of the 736 patients included in the study, 149 had complications. The 5-year overall and cancer-specific survival rates were significantly lower in patients with inflammatory respiratory complications. The Cox proportional hazard model showed that the inflammatory respiratory complications had a significant impact on overall survival (hazard ratio 2.48, 95% confidence interval 1.41–4.38) but not air leak (hazard ratio 1.38, 95% confidence interval 0.70–2.70). Our study shows the differential impact of each complication on the survival of patients with non-small cell lung cancer. The presence of inflammatory respiratory complications was the only predictor of poor overall survival. |
Databáze: | OpenAIRE |
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