| Autor: |
W, Rice, J, Martin, M, Hodgkin, J, Carter, A, Barrasa, K, Sweeting, R, Johnson, E, Best, J, Nahl, M, Denton, G J, Hughes |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of Hospital Infection. 132:52-61 |
| ISSN: |
0195-6701 |
| DOI: |
10.1016/j.jhin.2022.11.013 |
| Popis: |
Between September 2016 and November 2020, 17 cases of difficult-to-treat resistant Pseudomonas aeruginosa (DTR-PA) were reported in haematology patients at a tertiary referral hospital in the North of England.A retrospective case-control study was conducted to investigate the association between DTR-PA infection and clinical interventions, patient movement, antimicrobial use and co-morbidities.Cases were patients colonised or infected with the outbreak strain of DTR-PA who had been admitted to hospital prior to their positive specimen. A retrospective matched case-control study was performed. Exposures were extracted from medical records and cases were compared to controls using conditional logistic regression. Environmental and microbiological investigations were also conducted.17 cases and 51 controls were included. The final model included age (65,aOR 6.85,p=0.232), sex (aOR 0.60,p=0.688), admission under the transplant team (aOR 14.27,p=0.43) and ciprofloxacin use (aOR 102.13,p=0.030). Investigations did not indicate case-to-case transmission or a point source, although a common environmental source was highly likely.This study demonstrates fluoroquinolone use as an independent risk factor for DTR-PA in haematology patients. Antimicrobial stewardship and review of fluoroquinolone prophylaxis should be considered as part of PA outbreak investigations in addition to standard infection control interventions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect