Survival and risk factors related to death in outpatients with cirrhosis treated in a clinic in Southern Brazil
| Autor: | Priscila Contiero, Pedro Henrique Comerlato, Renata Rodrigues da Silva, Angelo Alves de Mattos, Mariana Porto, Suelen Aparecida da Silva Miozzo, Jorge Alberto John |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Carcinoma Hepatocellular Outpatient Clinics Hospital Cirrhosis MEDLINE Kaplan-Meier Estimate Risk Factors Internal medicine medicine Carcinoma Humans Outpatient clinic Aged Retrospective Studies Hepatology business.industry Public health Liver Neoplasms Gastroenterology Retrospective cohort study Hepatitis C Hepatitis C Chronic Middle Aged Prognosis medicine.disease Surgery body regions Cohort Female business |
| Zdroj: | European Journal of Gastroenterology & Hepatology. 27:1372-1377 |
| ISSN: | 0954-691X |
| Popis: | Cirrhosis represents a public health issue that generally evolves and presents serious complications.To assess the outcomes of outpatients with cirrhosis.We used a retrospective outpatient-based cohort, assessing 527 patients with cirrhosis. Demographic, clinical, and laboratory variables were analyzed, as well as the risk factors related to death, using the Cox proportional-hazard regression model. The Kaplan-Meier method was used to analyze survival rates.Patients had a mean age of 52.9±9.7 years and were more frequently men (59%), presenting Child-Turcotte-Pugh B or C in 43% of the cases in addition to a mean Model for End-Stage Liver Disease score of 12.0±4.1. The predominant etiology of liver disease was the hepatitis C virus. The most frequent complications during follow-up were ascites (34%), hepatic encephalopathy (17%), and hepatocellular carcinoma (17%). The survival rate at years 5 and 10 was 73 and 57%, respectively. The main risk factors that were related to death were, in a multivariate analysis, hepatitis C virus etiology, presence of hepatocellular carcinoma, and serum levels of albumin.Patients with cirrhosis monitored on an outpatient basis, despite showing a reasonable survival rate, have a worse prognosis when the etiology of liver disease is related to hepatitis C virus and when they have hepatocellular carcinoma or hypoalbuminemia. |
| Databáze: | OpenAIRE |
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