Is the effect of cognitive reserve in longitudinal outcomes in first-episode psychoses dependent on the use of cannabis?

Autor: Silvia Amoretti, Norma Verdolini, Cristina Varo, Gisela Mezquida, Ana M. Sánchez-Torres, Eduard Vieta, Clemente Garcia-Rizo, Antonio Lobo, Ana González-Pinto, Renzo Abregú-Crespo, Iluminada Corripio, Maria Serra, Elena de la Serna, Anna Mané, J Antoni Ramos-Quiroga, Marta Ribases, Manuel J Cuesta, Miguel Bernardo
Rok vydání: 2022
Předmět:
Zdroj: JOURNAL OF AFFECTIVE DISORDERS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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ISSN: 0165-0327
DOI: 10.1016/j.jad.2022.01.077
Popis: Background: Cognitive reserve (CR) is a protective factor against cognitive and functional impairment in first-episode psychosis (FEP). The aim of this study was to evaluate the differences in clinical presentation accord-ing to the use of cannabis (cannabis users vs non-users) among patients presenting a FEP (non-affective vs af-fective psychosis), to investigate the impact of CR and cannabis use on several outcomes and to explore the potentially mediatory role played by CR in the relationship between cognitive domains or clinical status and functionality, depending on the use of cannabis. Methods: Linear regression analysis models were carried out to assess the predictive value of CR on clinical, functional and cognitive variables at baseline and at two-year follow-up. The mediation analyzes were performed according to the principles of Baron and Kenny. Results: CR was associated with better cognitive performance, regardless of cannabis consumption or diagnosis. In both diagnoses, CR was associated with better clinical and functional outcomes in those patients who did not use cannabis. In terms of mediation procedure, CR mediates the relationship between some cognitive domains and functioning at follow-up only in patients without cannabis use. Limitations: The small sample size of the affective group. Conclusions: CR plays a differential role in the outcome of psychoses according to whether patients are cannabis users or not. Both in affective and non-affective groups CR exerted a greater effect in patients without cannabis use. Our results suggest that the deleterious effect of cannabis use on functioning in FEP surpasses the protective effect of CR.
Databáze: OpenAIRE
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