Genotypes distribution of human papillomavirus in cervical samples of Ecuadorian women

Autor: Franklin Almeida Carpio, Gustavo David García Muentes, Lindsay Karen García Rodriguez, Juan Carlos Ruiz Cabezas, Ramiro Israel Burgos Galárraga
Rok vydání: 2016
Předmět:
0301 basic medicine
Epidemiology
Uterine Cervical Neoplasms
Cervix Uteri
law.invention
0302 clinical medicine
law
Genotype
Prevalence
Papillomaviridae
Early Detection of Cancer
Polymerase chain reaction
Cervical cancer
education.field_of_study
Hpv types
Obstetrics
lcsh:Public aspects of medicine
HPV infection
virus diseases
General Medicine
Middle Aged
female genital diseases and pregnancy complications
030220 oncology & carcinogenesis
Female
Ecuador
Adult
Human papillomavirus
medicine.medical_specialty
Uterine cervical neoplasms
Population
Linear array
Young Adult
03 medical and health sciences
medicine
Humans
education
Reação em cadeia da polimerase
Aged
Gynecology
business.industry
Papillomavirus Infections
Equador Neoplasias do colo do útero
Public Health
Environmental and Occupational Health
lcsh:RA1-1270
medicine.disease
Papillomavirus humano
Cross-Sectional Studies
030104 developmental biology
business
Zdroj: Revista Brasileira de Epidemiologia v.19 n.1 2016
Revista brasileira de epidemiologia
Associação Brasileira de Saúde Coletiva (ABRASCO)
instacron:ABRASCO
Revista Brasileira de Epidemiologia, Vol 19, Iss 1, Pp 160-166 (2016)
ISSN: 1415-790X
DOI: 10.1590/1980-5497201600010014
Popis: Introduction: Human papillomavirus (HPV) is considered a necessary causative agent for developing oropharyngeal, anal and cervical cancer. Among women in Ecuadorian population, cervical cancer ranks as the second most common gynecological cancer. Not many studies about HPV burden have been published in Ecuador, and genotypes distribution has not been established yet. The little data available suggest the presence of other genotypes different than 16 and 18. Objectives: In the present study, we attempt to estimate the prevalence of HPV 16, HPV 18 and other 35 genotypes among Ecuadorian women undergoing cervical cancer screening. The overall prevalence of HPV infection was also estimated. Methods: Routine cervical samples were analyzed using Linear Array(r) HPV Genotyping test (Roche). Results: A total of 1,581 cervical samples obtained from Ecuadorian women undergoing cervical cancer screening were included in this study. HPV DNA was detected in 689 cervical samples (43.58%). Of these samples, 604 (38.20%) were positive for a single HPV genotype, while another 85 (5.37%) samples were positive for multiple HPV types. Genotype 16 (5.50%) resulted in the most frequently detected type in both single and multiple infections. HPV 33 (4.55%) and HPV 11 (3.80%) occupied the second and the third place in frequency among all detected genotypes. Conclusions: Viral genotypes different from HPV 16 and HPV 18 are frequently detected among Ecuadorian women. The overall prevalence of HPV resulted higher than the one reported in other South American countries with a greater burden in the second and third decades of life.
Databáze: OpenAIRE
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