Membranous nephropathy associated with immunoglobulin G4-related disease successfully treated with obinutuzumab

Autor:	Noemi E Ginthör, Katharina Artinger, Marion J Pollheimer, Martin H Stradner, Kathrin Eller
Rok vydání:	2021
Předmět:	Transplantation Nephrology fungi parasitic diseases
Zdroj:	Clinical Kidney Journal. 15:564-566
ISSN:	2048-8513 2048-8505
DOI:	10.1093/ckj/sfab250
Popis:	Immunoglobulin G4 (IgG4)-releated disease is typically associated with interstitial nephritis, but rare cases of idiopathic membranous nephropathy as a renal manifestation have been described. Obinutuzumab was successfully used in refractory membranous nephropathy, but evidence for the treatment of IgG4-related disease with obinutuzumab is lacking. We report one patient's case with membranous nephropathy associated with IgG4-related disease who was treated with obinutuzumab following an anaphylactic reaction to rituximab. Obinutuzumab treatment resulted in a sustained complete remission of membranous nephropathy and a decrease of IgG4 to the normal range. This case demonstrates that membranous nephropathy associated with IgG4-related disease can be treated successfully with obinutuzumab.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247ec7ccfa906834e89893ad85762a82 https://doi.org/10.1093/ckj/sfab250 Zobrazit plný text záznamu