Proposed link between Helicobacter pylori and sudden infant death syndrome
| Autor: | CP Pattison, Barry J. Marshall |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
biology
Helicobacter pylori business.industry Respiratory arrest Respiratory disease Infant Newborn Infant General Medicine Sudden infant death syndrome biology.organism_classification medicine.disease Sudden death Proinflammatory cytokine Hypoxemia Helicobacter Infections Immune system Risk Factors Immunology medicine Humans medicine.symptom business Sudden Infant Death |
| Zdroj: | Medical hypotheses. 49(5) |
| ISSN: | 0306-9877 |
| Popis: | Helicobacter pylori may be linked to sudden infant death syndrome (SIDS) through synthesis of inflammatory cytokines, particularly interleukin-1, which can produce fever, activation of the immune system, and increased deep sleep. A relatively minor respiratory or enteric infection, together with overwrapping and prone sleep position could then induce terminal hypoxemia. Alternatively, H. pylori produces large amounts of urease which, if aspirated in gastric juice, could reach the alveolae, react with plasma urea, and produce ammonia toxicity leading to respiratory arrest. Epidemiological similarities between H. pylori and SIDS are presented along with possible transmission mechanisms for H. pylori which support this hypothesis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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