Diminished and waning immunity to COVID-19 vaccination among hemodialysis patients in Israel: the case for a third vaccine dose
| Autor: | Nomy Levin Iaina, Tal Brosh-Nissimov, Avital Angel-Korman, Zeev Katzir, Victoria Indenbaum, Adi Leiba, Yoram Yagil, Esther Peres, Yaniv Lustig, Gabriel Bryk, Vladimir Rappoport, Sharon Amit |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Transplantation
Pediatrics medicine.medical_specialty BNT162b2 vaccine hemodialysis Coronavirus disease 2019 (COVID-19) business.industry medicine.medical_treatment COVID-19 waning immunity Vaccination Nephrology medicine Original Article neutralizing antibodies Waning immunity Hemodialysis business AcademicSubjects/MED00340 anti-S antibodies seroconversion humoral response |
| Zdroj: | Clinical Kidney Journal |
| ISSN: | 2048-8513 2048-8505 |
| Popis: | Background Humoral responses to COVID-19 vaccines in hemodialysis patients can direct vaccination policy. Methods We compared 409 COVID-19 naïve hemodialysis patients from 13 hemodialysis units in Israel to 148 non-dialysis dependent COVID-19 naïve controls. Twenty-four previously infected (anti-nucleocapsid positive) hemodialysis patients were analyzed separately. Blood samples were obtained ≥ 14 days post vaccination (BNT162b2) to assess seroconversion-rates and titers of anti-S and neutralizing antibodies. Results Median time from vaccination to blood sample collection was 82 (IQR 64–87) and 89 (IQR 68–96) days, for hemodialysis patients and controls, respectively. Seroconversion rates were lower in hemodialysis patients compared to controls for both anti-S and neutralizing antibodies (89% and 77% vs. 99.3%, respectively, P Graphical Abstract Graphical Abstract |
| Databáze: | OpenAIRE |
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