Gastric cancer patients less than 50 years of age exhibit significant downregulation of E-cadherin and CDX2 compared to older reference populations
| Autor: | Roland S. Croner, Heike Allgayer, Abbas Agaimy, Arno Dimmler, Susanne Merkel, Claus Schildberg, Werner Hohenberger, Mohammed Abba, Anne Schlabrakowski, Jörg H. Leupold |
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| Rok vydání: | 2013 |
| Předmět: |
Oncology
Male medicine.medical_specialty Pathology Context (language use) CDH1 Immunoenzyme Techniques Reference Values Stomach Neoplasms Internal medicine Germany medicine Biomarkers Tumor Humans CDX2 Transcription Factor CDX2 Survival rate Neoplasm Staging Retrospective Studies Homeodomain Proteins biology Cadherin business.industry Cancer Retrospective cohort study General Medicine Middle Aged medicine.disease Cadherins Prognosis Combined Modality Therapy digestive system diseases Survival Rate Tissue Array Analysis biology.protein Immunohistochemistry Female business Follow-Up Studies |
| Zdroj: | Advances in medical sciences. 59(1) |
| ISSN: | 1898-4002 |
| Popis: | Purpose There is an increasing need to identify molecular markers, which can be used to prognosticate patient populations in gastric cancer. Whereas a significant number have been identified, very few have been characterized in the context of their ability to discriminate between young and old age groups in which a survival difference clearly exists. Material/methods In this study, using immunohistochemistry, we evaluated three markers with proven involvement in gastric cancer. The p53 tumor suppressor, the cell adhesion glycoprotein epithelial cadherin (CDH1) and the caudal-related homeobox transcription factor (CDX2) all of these have important roles in the aetiopathogenesis and/or progression of gastric cancer. Results After adjustments for TNM stage, tumor grade, histopathological characteristics (Lauren classification), we found significant differences in the expression of these proteins, particularly E-cadherin and CDX2 between young and elderly patients. However, these differences did not amount to a significant difference in survival. Conclusions This study demonstrates that the protein expression of p53, CDH1 and CDX2 significantly discriminates young patients with gastric cancer who have a better prognostic outlook from older patients, but this difference in expression does not contribute to a survival benefit. |
| Databáze: | OpenAIRE |
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