Ifosfamide in plasma cell leukemia: A report of two cases and review of the literature
| Autor: | Suresh H. Advani, Malhotra H, Dhabhar Bn, Ramkrishnan Gopal, Chandrika N. Nair, Nadkarni Ks, Tapan K. Saikia |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Myeloma protein medicine.medical_treatment Plasma cell Gastroenterology Leukemia Plasma Cell Internal medicine medicine Humans Ifosfamide Multiple myeloma Plasma cell leukemia Chemotherapy business.industry Hematology Middle Aged medicine.disease Peripheral blood medicine.anatomical_structure Female Bone marrow business medicine.drug |
| Zdroj: | American Journal of Hematology. 40:226-228 |
| ISSN: | 1096-8652 0361-8609 |
| Popis: | We report two patients with primary plasma cell leukemia (PCL) treated with a single agent, ifosfamide. One patient had a total disappearance of plasma cells (PC) from the peripheral blood and the bone marrow and disappearance of the myeloma protein, is disease free 8 months after completion of treatment, and alive 14 months after diagnosis. The second patient had a partial response with persistence of plasma cells in the bone marrow lasting 7 months, after which she had a frank relapse of the disease. We suggest that ifosfamide may be an active agent in plasma cell malignancies and needs further evaluation in multiple myeloma. © 1992 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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