Imaging the Distribution of Gastrin-Releasing Peptide Receptors in Cancer
| Autor: | Lucia Baratto, Heying Duan, Helmut R. Mäcke, Andrei Iagaru |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Peptide Breast Neoplasms 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound Prostate cancer 0302 clinical medicine Gastrin-releasing peptide medicine Humans Radiology Nuclear Medicine and imaging Tissue Distribution Receptor chemistry.chemical_classification Chemistry Immunogenicity Bombesin Cancer Prostatic Neoplasms medicine.disease Small molecule Receptors Bombesin Gastrin-Releasing Peptide 030220 oncology & carcinogenesis Cancer research Female Radiopharmaceuticals |
| Zdroj: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 61(6) |
| ISSN: | 1535-5667 |
| Popis: | Targeting tumor-expressed receptors using selective molecules for diagnostic, therapeutic, or both diagnostic and therapeutic (theragnostic) purposes is a promising approach in oncologic applications. Such approaches have increased significantly over the past decade. Peptides such as gastrin-releasing peptide receptors targeting radiopharmaceuticals are small molecules with fast blood clearance and urinary excretion. They demonstrate good tissue diffusion, low immunogenicity, and highly selective binding to their target cell-surface receptors. They are also easily produced. Gastrin-releasing peptide receptors, part of the bombesin family, are overexpressed in many tumors, including breast and prostate cancer, and therefore represent an attractive target for future development. |
| Databáze: | OpenAIRE |
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