Alteration of erythrocyte membrane polyunsaturated fatty acids in preterm newborns with retinopathy of prematurity
| Autor: | Stéphane Grégoire, Niyazi Acar, Denis S. Semama, Julie Mazzocco, Ninon Ternoy, Charlotte Pallot, Cyril Meillon, Lionel Bretillon, Catherine Creuzot-Garcher, Corinne Chantegret, Alain M. Bron, Delphine Martin, Aurélie Donier |
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| Přispěvatelé: | Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Centre National de la Recherche Scientifique (CNRS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB), Université Bourgogne Franche-Comté [COMUE] (UBFC), This work has been funded by the Regional Council of Burgundy France (PARI Agral 1), FEDER (European Funding for Regional Economical Development), Association Nationale Recherche Technologie, Fondation de France/Fondation de l’Oeil, Agence Nationale de la Recherche [ANR-11-LABEX-0021]., Acar, Niyazi |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Organes des sens prémature lcsh:Medicine fatty acids retinopathy of prematury chemistry.chemical_compound 0302 clinical medicine Prospective Studies lcsh:Science Prospective cohort study chemistry.chemical_classification Multidisciplinary Gestational age Retinopathy of prematurity 3. Good health Docosahexaenoic acid In utero Alimentation et Nutrition Fatty Acids Unsaturated Female lipids (amino acids peptides and proteins) Arachidonic acid Animal studies Infant Premature Polyunsaturated fatty acid medicine.medical_specialty rétine Sensory Organs Médecine humaine et pathologie Gestational Age Article 03 medical and health sciences Fatty Acids Omega-6 Internal medicine Fatty Acids Omega-3 medicine Food and Nutrition Humans [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs Fatty acids acide gras oméga 6 business.industry lcsh:R Erythrocyte Membrane Infant Newborn acide gras oméga 3 medicine.disease eye diseases 030104 developmental biology Endocrinology chemistry lcsh:Q Human health and pathology business [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.7930. ⟨10.1038/s41598-019-44476-w⟩ Scientific Reports 1 (9), 7930. (2019) Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Extremely preterm infants are at high risk for retinopathy of prematurity (ROP), a potentially blinding disease characterized by abnormalities in retinal vascularization. Whereas animal studies revealed that n-3 polyunsaturated fatty acids (PUFAs) may be of benefit in preventing ROP, human studies conducted on preterm infants during the 1st weeks of life showed no association between blood n-3 PUFA bioavailability and ROP incidence and/or severity, probably because of the influence of nutrition on the lipid status of infants. In the OmegaROP prospective cohort study, we characterized the erythrocyte concentrations of PUFAs in preterm infants aged less than 29 weeks gestational age (GA) without any nutritional influence. We show that GA is positively associated with the erythrocyte n-6 to n-3 PUFA ratio, and particularly with the ratio of arachidonic acid (AA) to docosahexaenoic acid (DHA), in infants with ROP. A time-dependent accumulation of AA at the expense of DHA seems to occur in utero in erythrocytes of preterm infants who will develop ROP, thus reinforcing previous data on the beneficial properties of DHA on this disease. In addition, preliminary data on maternal erythrocyte membrane lipid concentrations suggest modifications in placental transfer of fatty acids. Documenting the erythrocyte AA to DHA ratio at birth in larger cohorts might be useful to set up new prognostic factors for ROP. |
| Databáze: | OpenAIRE |
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