Assessment of Immune Cell Populations in Tumor Tissue and Peripheral Blood Samples from Head and Neck Squamous Cell Carcinoma Patients
| Autor: | Adriana Narcisa Munteanu, Liliana Moraru, Monica Neagu, Ana Caruntu, Constantin Caruntu, Sabina Zurac, Mihaela Surcel, Cristiana Tanase, Carolina Constantin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research Article Subject Helper T lymphocyte Lymphocyte chemical and pharmacologic phenomena CD19 Pathology and Forensic Medicine Lymphocytes Tumor-Infiltrating Immune system Tumor Microenvironment medicine Humans Cytotoxic T cell RC254-282 Aged Aged 80 and over Tumor microenvironment biology QH573-671 Squamous Cell Carcinoma of Head and Neck business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cell Biology General Medicine Middle Aged medicine.disease Head and neck squamous-cell carcinoma medicine.anatomical_structure Head and Neck Neoplasms biology.protein Cancer research Molecular Medicine Female business Cytology CD8 Research Article |
| Zdroj: | Analytical Cellular Pathology, Vol 2021 (2021) Analytical Cellular Pathology (Amsterdam) |
| ISSN: | 2210-7185 2210-7177 |
| Popis: | Head and neck squamous cell carcinoma (HNSCC) is a common type of cancer worldwide. Strong connections have been revealed between immune cells and the pathogenesis of HNSCC. Important differences regarding the levels of immune cell subpopulations in both peripheral circulation and tumor microenvironment were emphasized, with some of them having prognostic significance. In our study, we performed an analysis of immune changes in the tumor tissue and the peripheral blood of untreated HNSCC patients, investigating the proportions of different immune cell populations in these two compartments. The local infiltrating lymphocytes were mainly cytotoxic T cells (CD8+). We have also revealed an increased level of B lymphocytes (CD19+) in the tumor microenvironment. In peripheral blood, the most important lymphocyte subtype was represented by the helper T lymphocytes (CD4+). We also found an increased proportion of circulating NK cells (CD56+). Our results showed significant differences between all investigated lymphocyte subtypes in the peripheral blood and the tumor tissue of untreated HNSCC patients, suggesting that the local and systemic expressions of antitumor immune responses are different and that investigation of immune cell proportions in peripheral circulation has different cues that do not reflect the immune infiltrate pattern within the tumor microenvironment. Further studies are necessary to unveil the complex interplay involving local and systemic events in the immune system’s fight against cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text