Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice

Autor: Chen Xiaoqiang, Jianrong Li, Shikang Zhang, Haitong Wan, Sudan Ye, Hongying Zhu, Yin Lu, Gaoli Zheng
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Blood Glucose
FTY720
Nod
type 1 diabetes (T1D)
Kidney
lcsh:Chemistry
Mice
Non obese
Mice
Inbred NOD
Sphingosine
hemic and lymphatic diseases
lcsh:QH301-705.5
Physiological saline
Spectroscopy
NOD mice
biology
Glutamate Decarboxylase
General Medicine
Computer Science Applications
medicine.anatomical_structure
Liver
Female
Antibody
Immunosuppressive Agents
medicine.medical_specialty
Spleen
Catalysis
Article
Inorganic Chemistry
Internal medicine
Diabetes mellitus
medicine
Animals
Physical and Theoretical Chemistry
Molecular Biology
business.industry
Fingolimod Hydrochloride
non-obese diabetic (NOD) mice
Organic Chemistry
Body Weight
medicine.disease
Disease Models
Animal
physiological indexes
Endocrinology
Diabetes Mellitus
Type 1
lcsh:Biology (General)
lcsh:QD1-999
Propylene Glycols
Immunology
biology.protein
business
Zdroj: International Journal of Molecular Sciences
Volume 13
Issue 5
Pages 6129-6137
International Journal of Molecular Sciences, Vol 13, Iss 5, Pp 6129-6137 (2012)
ISSN: 1422-0067
DOI: 10.3390/ijms13056129
Popis: The studies were performed to investigate the physiological characteristics of non-obese diabetic (NOD) mice treated with FTY720. At the age of 12 weeks, each mouse was fed with FTY720 or physiological saline once a day for 10 weeks running, and their blood glucose, weight, anti-GAD antibody and organ indexes were determined. No mouse in group FTY720 (NOD mice treated with FTY720) showed diabetic symptoms. The average content of serum anti-GAD antibody in group FTY720 decreased 48.75% (P < 0.01). It was concluded that the spleen, kidney and liver of NOD mice treated with FTY720 shriveled significantly in the progression of diabetes (P < 0.01 or P < 0.05). The body weight of group FTY720 mice was slightly lower than that of the model control (MC) group and these two groups both had less body weight than the normal control (NC) group (P < 0.01). The result of tests of anti-GAD antibody suggested that FTY720 treatment could suppress the anti-GAD response.
Databáze: OpenAIRE
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