Targeting netrin‐1/ DCC interaction in diffuse large B‐cell and mantle cell lymphomas

Autor: Catherine Chassagne-Clément, Jean-Guy Delcros, Marie Castets, Jonathan Vial, Antonin Tortereau, Amélie Colombe, Gilles Salles, Céline Pangault, Sophie Léon, Karin Tarte, Guillaume Chazot, Olivier Donzé, Nicolas Gadot, Patrick Mehlen, Laura Broutier, Marion Creveaux, Mark J. McCarron, Jonathan Blachier, Julien C. Marie, Alexandra Traverse-Glehen, Marie-Laure Boulland
Přispěvatelé: Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Développement Cancer et Thérapies Ciblées [Lyon] (LabEx DEVweCAN), Université de Lyon, Interactions Cellules Environnement - UR (ICE), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Microenvironnement et cancer (MiCa), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Anipath, UFR Médecine Lyon-RTH Laennec, Service d'Hématologie, Immunologie et de Thérapie Cellulaire (HITC), Université de Rennes (UR)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Laboratoire de Biologie Moléculaire de la Cellule (LBMC), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Service d'Anatomie Pathologique, Hospices Civils de Lyon (HCL), Département d'anatomopathologie, biopathologie, Centre Léon Bérard [Lyon], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Service d’immunologie, de thérapie cellulaire et d’hématopoïèse, Hôpital Pontchaillou, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon
Rok vydání: 2016
Předmět:
0301 basic medicine
Pathology
Deleted in Colorectal Cancer
[SDV]Life Sciences [q-bio]
Cell
Lymphoma
Mantle-Cell
Mice
immune system diseases
hemic and lymphatic diseases
Netrin
non‐Hodgkin lymphoma
DCC
Cancer
non-Hodgkin lymphoma
apoptosis
Netrin-1
DCC Receptor
3. Good health
netrin‐1
medicine.anatomical_structure
embryonic structures
Heterografts
Molecular Medicine
Lymphoma
Large B-Cell
Diffuse
Protein Binding
medicine.medical_specialty
animal structures
Antineoplastic Agents
Mice
Transgenic
Receptors
Cell Surface
Biology
Antibodies
03 medical and health sciences
Cell Line
Tumor
Report
dependence receptors
medicine
Animals
Humans
Nerve Growth Factors
B cell
Tumor Suppressor Proteins
fungi
Germinal center
medicine.disease
Lymphoma
Disease Models
Animal
030104 developmental biology
Tumor progression
Cancer research
Mantle cell lymphoma
Haematology
Reports
Zdroj: EMBO Molecular Medicine
EMBO Molecular Medicine, 2016, 8 (2), pp.96--104. ⟨10.15252/emmm.201505480⟩
EMBO Molecular Medicine, Wiley Open Access, 2016, 8 (2), pp.96--104. ⟨10.15252/emmm.201505480⟩
ISSN: 1757-4684
1757-4676
DOI: 10.15252/emmm.201505480
Popis: International audience; DCC (Deleted in Colorectal Carcinoma) has been demonstrated to constrain tumor progression by inducing apoptosis unless engaged by its ligand netrin-1. This has been shown in breast and colorectal cancers; however, this tumor suppressive function in other cancers is not established. Using a transgenic mouse model, we report here that inhibition of DCC-induced apoptosis is associated with lymphomagenesis. In human diffuse large B-cell lymphoma (DLBCL), an imbalance of the netrin-1/DCC ratio suggests a loss of DCC-induced apoptosis, either via a decrease in DCC expression in germinal center subtype or by up-regulation of netrin-1 in activated B-cell (ABC) one. Such imbalance is also observed in mantle cell lymphoma (MCL). Using a netrin-1 interfering antibody, we demonstrate both in vitro and in vivo that netrin-1 acts as a survival factor for ABC-DLBCL and MCL tumor cells. Together, these data suggest that interference with the netrin-1/DCC interaction could represent a promising therapeutic strategy in netrin-1-positive DLBCL and MCL
Databáze: OpenAIRE
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