Pharmacogenomic considerations for medications in the perioperative setting
| Autor: | Peter H. O'Donnell, Keith Danahey, David M. Dickerson, Jeffrey L. Apfelbaum, Ellie H. Jhun, Sajid Shahul, Randall W. Knoebel, Mark J. Ratain |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Drug-Related Side Effects and Adverse Reactions Adverse outcomes Review 030226 pharmacology & pharmacy Perioperative Care 03 medical and health sciences 0302 clinical medicine Inadequate analgesia Genetics medicine Humans Genetic Predisposition to Disease Genetic Testing Precision Medicine Intensive care medicine Depression (differential diagnoses) Pharmacology business.industry Medication risk Perioperative Precision medicine Pharmacogenomic Testing Pharmacogenetics Pharmacogenomics Molecular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Pharmacogenomics |
| ISSN: | 1744-8042 |
| Popis: | Several high-profile examples of adverse outcomes from medications used in the perioperative setting are well known (e.g., malignant hyperthermia, prolonged apnea, respiratory depression, inadequate analgesia), leading to an increased understanding of genetic susceptibilities underlying these risks. Pharmacogenomic information is increasingly being utilized in certain areas of medicine. Despite this, routine preoperative genetic screening to inform medication risk is not yet standard practice. In this review, we assess the current readiness of pharmacogenomic information for clinical consideration for several common perioperative medications, including description of key pharmacogenes, pharmacokinetic implications and potential clinical outcomes. The goal is to highlight medications for which emerging or considerable pharmacogenomic information exists and identify areas for future potential research. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|