The Yeast vps Class E Mutants: The Beginning of the Molecular Genetic Analysis of Multivesicular Body Biogenesis
| Autor: | Emily M. Coonrod, Tom H. Stevens |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Saccharomyces cerevisiae Proteins
Endosome Retrospective Mutant Vesicular Transport Proteins Golgi Apparatus Endosomes Saccharomyces cerevisiae macromolecular substances Vacuole Biology 03 medical and health sciences symbols.namesake 0302 clinical medicine Lysosome medicine Molecular Biology 030304 developmental biology Vacuolar protein sorting 0303 health sciences Golgi membrane Endosomal Sorting Complexes Required for Transport Vesicle Multivesicular Bodies Cell Biology History 20th Century Golgi apparatus Cell biology medicine.anatomical_structure Biochemistry Mutation Vacuoles symbols 030217 neurology & neurosurgery |
| Zdroj: | Molecular Biology of the Cell |
| ISSN: | 1939-4586 1059-1524 |
| Popis: | In 1992, Raymond et al. published a compilation of the 41 yeast vacuolar protein sorting (vps) mutant groups and described a large class of mutants (class E vps mutants) that accumulated an exaggerated prevacuolar endosome-like compartment. Further analysis revealed that this “class E compartment” contained soluble vacuolar hydrolases, vacuolar membrane proteins, and Golgi membrane proteins unable to recycle back to the Golgi complex, yet these class E vps mutants had what seemed to be normal vacuoles. The 13 class E VPS genes were later shown to encode the proteins that make up the complexes required for formation of intralumenal vesicles in late endosomal compartments called multivesicular bodies, and for the sorting of ubiquitinated cargo proteins into these internal vesicles for eventual delivery to the vacuole or lysosome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|