Nocturnal Monitoring of Growth Hormone, Insulin, C-Peptide, and Glucose in Patients With Acromegaly
| Autor: | Lilian L. Zorrilla, Saul Rosenberg, David L. Marcus, Kirsten K. Jacob, Jir S. Tsai |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty medicine.medical_treatment Nocturnal Growth hormone Body Mass Index chemistry.chemical_compound Pituitary Gland Anterior Internal medicine Hyperinsulinism Acromegaly Insulin Secretion medicine Humans Insulin Pancreas Morning C-Peptide business.industry C-peptide Fasting General Medicine Glucose Tolerance Test medicine.disease Growth hormone secretion Circadian Rhythm Endocrinology chemistry Growth Hormone Female business Secretory Rate Sleep |
| Zdroj: | The American Journal of the Medical Sciences. 311:281-285 |
| ISSN: | 0002-9629 |
| DOI: | 10.1097/00000441-199606000-00010 |
| Popis: | Circulating growth hormone, insulin, C-peptide, and glucose levels were compared during the sleep state in adults with acromegaly and healthy control subjects. Growth hormone secretion was episodic in both groups, with the sleep-related growth hormone peak noticeably absent in the acromegalic subjects. The mean nocturnal plasma insulin concentration was greater in the acromegalics. There was no significant difference in the C-peptide between the two groups. Insulin and glucose levels did not show an early morning rise in either acromegalics or healthy subjects. The authors conclude that there is a marked difference in the circulating levels of growth hormone and insulin between the acromegalic and the healthy groups during the sleep state, and there is no sleep-related nocturnal growth hormone peak in the acromegalic subjects. The hyperinsulinism of patients with acromegaly cannot be attributed to excess secretion of insulin. |
| Databáze: | OpenAIRE |
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