Gestational malaria associated to Plasmodium vivax and Plasmodium falciparum placental mixed-infection followed by foetal loss: a case report from an unstable transmission area in Brazil
| Autor: | Fernanda Maria Franzin, Marcus V. G. Lacerda, Gustavo B. Gregoracci, Joycenea da Silva Matsuda, Fabio T. M. Costa, Juliana A. Leite, Paulo Nogueira, Flor Ernestina Martinez-Espinosa, Bruna O. Carvalho, Patrícia Puccinelli Orlandi, Sérgio Luiz Bessa Luz |
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| Jazyk: | angličtina |
| Předmět: |
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962 Placenta Plasmodium vivax Population Plasmodium falciparum Case Report Prenatal care Abortion Septic Polymerase Chain Reaction lcsh:Infectious and parasitic diseases Young Adult Pregnancy parasitic diseases Malaria Vivax Medicine Humans lcsh:RC109-216 Malaria Falciparum Pregnancy Complications Infectious education education.field_of_study Microscopy biology business.industry Transmission (medicine) biology.organism_classification medicine.disease Infectious Diseases Parasitology Immunology Female business Malaria Brazil |
| Zdroj: | Malaria Journal, Vol 10, Iss 1, p 178 (2011) Malaria Journal |
| ISSN: | 1475-2875 |
| DOI: | 10.1186/1475-2875-10-178 |
| Popis: | Gestational malaria is a multi-factorial syndrome leading to poor outcomes for both the mother and foetus. Although an unusual increasing in the number of hospitalizations caused by Plasmodium vivax has been reported in Brazil, mortality is rarely observed. This is a report of a gestational malaria case that occurred in the city of Manaus (Amazonas State, Brazil) and resulted in foetal loss. The patient presented placental mixed-infection by Plasmodium vivax and Plasmodium falciparum after diagnosis by nested-PCR, however microscopic analysis failed to detect P. falciparum in the peripheral blood. Furthermore, as the patient did not receive proper treatment for P. falciparum and hospitalization occurred soon after drug treatment, it seems that P. falciparum pathology was modulated by the concurrent presence of P. vivax. Collectively, this case confirms the tropism towards the placenta by both of these species of parasites, reinforces the notion that co-existence of distinct malaria parasites interferes on diseases' outcomes, and opens discussions regarding diagnostic methods, malaria treatment during pregnancy and prenatal care for women living in unstable transmission areas of malaria, such as the Brazilian Amazon. |
| Databáze: | OpenAIRE |
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