Effects of footshock stress on superoxide dismutase and glutathione peroxidase enzyme activities and thiobarbituric acid reactive substances levels in the rat prefrontal cortex and striatum
| Autor: | Osman Açikgöz, Nazan Uysal, Sevil Gönenç, Berkant Muammer Kayatekin, Mustafa Akhisaroglu |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Thiobarbituric acid Prefrontal Cortex Striatum Nucleus accumbens Thiobarbituric Acid Reactive Substances behavioral disciplines and activities Superoxide dismutase chemistry.chemical_compound Stress Physiological Dopamine Internal medicine medicine Animals Rats Wistar Prefrontal cortex chemistry.chemical_classification Electroshock Glutathione Peroxidase biology Foot Superoxide Dismutase Chemistry General Neuroscience Glutathione peroxidase Corpus Striatum Rats Endocrinology nervous system behavior and behavior mechanisms biology.protein psychological phenomena and processes Peroxidase medicine.drug |
| Zdroj: | Neuroscience Letters. 289:107-110 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/s0304-3940(00)01272-6 |
| Popis: | Mild footshock stress results in an increase dopamine metabolism in the prefrontal cortex. Increases in either the intensity or duration of stress enhance dopamine metabolism in the nucleus accumbens and striatum, as well as in the prefrontal cortex. Dopamine is metabolized by monoamine oxidase with hydrogen peroxide as a product. In this study we have demonstrated that while very mild (0.2 mA) footshock stress did not change glutathione peroxidase activity in the rat prefrontal cortex and striatum, more intense (1.6 mA) footshock stress increased glutathione peroxidase activity at 0, 15, 30 and 60 min after the footshock in the prefrontal cortex and at 30 min after the footshock in the striatum. Stress did not change superoxide dismutase activity and thiobarbituric acid reactive substances levels. These results indicate that increased dopamine metabolism induced by footshock stress is probably responsible for the increase of glutathione peroxidase activity. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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