Sonographic assessment of endometrial pattern and thickness in patients treated with human menopausal gonadotropins
| Autor: | Michael Bohrer, Doreen L. Hock, Ekkehard Kemmann, George G. Rhoads |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Infertility medicine.medical_specialty Menotropins Pregnancy Rate Fertilization in Vitro Endometrium Chorionic Gonadotropin Pregnancy medicine Humans Prospective Studies Prospective cohort study Ultrasonography Gynecology Dose-Response Relationship Drug business.industry Obstetrics Female infertility Obstetrics and Gynecology medicine.disease Pregnancy rate medicine.anatomical_structure Reproductive Medicine Female Menotropin business Infertility Female |
| Zdroj: | Fertility and Sterility. 66:244-247 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)58447-7 |
| Popis: | Objective To analyze sonographically the endometrium in patients undergoing controlled ovarian stimulation with menotropins in order to determine the significance of endometrial pattern and thickness on pregnancy rate. Design This is a prospective, nonrandomized study comparing pregnancy rates in patients with hyperechoic homogeneous patterns with those in patients with isoechoic or hypoechoic trilaminar patterns. Setting Tertiary infertility center. Patients All patients receiving menotropin therapy at a tertiary infertility center. Interventions All patients received individualized dosing of hMG starting on cycle day 3. Transvaginal sonography was performed 15 hours before hCG administration and the endometrium was assessed. Main Outcome Measure Occurrence of pregnancy as determined by serially rising β-hCG titers and sonographic confirmation. Results During the study period, 175 patients were evaluated. Thirty-four (19%) patients had a homogeneous endometrium, whereas 141 (81%) patients had a trilaminar pattern. There was 1 pregnancy (2.9%) among women with a homogeneous endometrial pattern and 33 pregnancies (23%) among those with a trilaminar pattern. No significant differences were found in mean E2 level, follicle numbers, parity, and diagnosis between the two groups. Conclusion In patients receiving menotropins, a homogeneous pattern is a bad prognostic sign, regardless of endometrial thickness. |
| Databáze: | OpenAIRE |
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