Supplementary Tables from SNP rs16906252C>T Is an Expression and Methylation Quantitative Trait Locus Associated with an Increased Risk of Developing MGMT-Methylated Colorectal Cancer

Autor: Megan P. Hitchins, Nicholas J. Hawkins, Jake Olivier, Mark A. Jenkins, John L. Hopper, Ingrid M. Winship, Melissa C. Southey, Christophe Rosty, Mark Clendenning, Aung Ko Win, Daniel D. Buchanan, Robyn L. Ward, Robert W. Rapkins, Fan Wang, Joice Kuroiwa-Trzmielina
Rok vydání: 2023
Popis: Supplementary Table 1. Statistical comparisons between the methylation status of the MGMT promoter within colorectal carcinoma (CRC) and clinicopathological features, molecular features of tumors, and rs16906252C>T genotype in cases from the Sydney CRC series. Supplementary Table 2. Statistical comparisons of the methylation status of the MGMT promoter within the colorectal carcinoma (CRC) of cases from the Australasian Colorectal Cancer Family Registry (ACCFR). Supplementary Table 3. Performance of the rs16906252C>T genotype in predicting the MGMT methylation status of the primary CRC of cases from the Sydney and Australasian colon cancer family registry (ACCFR) CRC series. Supplementary Table 4. MGMT methylation in normal tissues of a subset of colorectal cancer cases and healthy controls is associated with the rs16906252C>T variant. Supplementary Table 5. Performance of the rs16906252C>T genotype and presence of lowlevel MGMT methylation in normal tissues of CRC cases in predicting the MGMT methylation status of the primary CRC in a subset of 62 cases from the Sydney CRC series.
Databáze: OpenAIRE