Disruption of zinc and copper interactions with Aβ(1-40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer's disease therapy?
| Autor: | Jesus Landeira-Fernandez, Daphne S. Cukierman, Nicolás A. Rey, Rachel Ann Hauser-Davis, L. V. de Freitas, Ariel A. Valiente-Gabioud, Claudio O. Fernández, Marco C. Miotto, W. S. Cruz |
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| Rok vydání: | 2015 |
| Předmět: |
Drug
Male media_common.quotation_subject In silico Biophysics Hydrazone Pharmacology Biochemistry Biomaterials In vivo Alzheimer Disease medicine Isoniazid Animals Homeostasis Humans Rats Wistar media_common chemistry.chemical_classification Amyloid beta-Peptides Chemistry Metals and Alloys Hydrazones In vitro Acute toxicity Peptide Fragments Zinc Chemistry (miscellaneous) Blood-Brain Barrier Copper medicine.drug |
| Zdroj: | Metallomics : integrated biometal science. 7(5) |
| ISSN: | 1756-591X |
| Popis: | Disruptions of biometal-Aβ(1-40) interactions by an isoniazid-derived hydrazone, INHHQ, were demonstrated via in vitro NMR titrations. The compound has adequate theoretical BBB absorption properties, assessed by in silico studies. In vivo acute toxicity assays indicate that INHHQ is innocuous up to 300 mg kg(-1), showing potential as an anti-Alzheimer's drug. |
| Databáze: | OpenAIRE |
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