Frequency of hereditary nonpolyposis colorectal cancer in southern Alberta
| Autor: | S. A. Huchcroft, Lloyd R. Sutherland, Heather Bryant, P. J. Westlake |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Dukes stage medicine.medical_specialty Adolescent Physiology Colorectal cancer Rectum Adenocarcinoma Gastroenterology Alberta Internal medicine medicine Humans Family Survival rate Aged Neoplasm Staging business.industry Incidence (epidemiology) Incidence Neoplasms Second Primary Hepatology Middle Aged medicine.disease Anus Neoplasms Pedigree Survival Rate medicine.anatomical_structure Female business Colorectal Neoplasms Cohort study |
| Zdroj: | Digestive diseases and sciences. 36(10) |
| ISSN: | 0163-2116 |
| Popis: | The frequency of hereditary nonpolyposis colorectal cancer was evaluated in a group of colorectal cancer patients under age 50 diagnosed in southern Alberta between 1973 and 1987. Families were identified as positive for this syndrome if three first-degree relatives in the kindred had colorectal cancer. Of the 390 patients with adenocarcinoma, 318 patients participated. The frequency of hereditary nonpolyposis colorectal cancer was 3.1% (12 families) in this group (Ci95 1.6-5.3%). Clinical characteristics reported on from the index patients include tumor location, Dukes stage at presentation, frequency of synchronous and metachronous tumors, frequency of second primaries, and survival. The 5- and 10-year actuarial survival was 86% and 69%, respectively. |
| Databáze: | OpenAIRE |
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