Radiothérapie stéréotaxique extra crânienne. Comment mieux protéger les tissus sains ?
| Autor: | X. Mirabel, L. Vanquin, David Pasquier, C. Brassart, Thomas Lacornerie, E. Lartigau |
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| Přispěvatelé: | Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2019 |
| Předmět: |
Systematic error
medicine.medical_specialty Modalities business.industry [SDV]Life Sciences [q-bio] Normal tissue Dose fractionation 3. Good health Imaging modalities 03 medical and health sciences 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Random error medicine High doses Radiology Nuclear Medicine and imaging Medical physics business Stereotactic body radiotherapy |
| Zdroj: | Cancer/Radiothérapie Cancer/Radiothérapie, 2019, 23, pp.630-635. ⟨10.1016/j.canrad.2019.07.153⟩ Cancer Radiothérapie Cancer Radiothérapie, Elsevier Masson, 2019, 23, pp.630-635. ⟨10.1016/j.canrad.2019.07.153⟩ |
| ISSN: | 1278-3218 1769-6658 |
| Popis: | The use of stereotactic body radiotherapy (SBRT) has increased rapidly over the past decade. Optimal preservation of normal tissues is a major issue because of their high sensitivity to high doses per session. Extreme hypofractionation can convert random errors into systematic errors. Optimal preservation of organs at risk requires first of all a rigorous implementation of this technique according to published guidelines. The robustness of the imaging modalities used for planning, and training medical and paramedical staff are an integral part of these guidelines too. The choice of SBRT indications, dose fractionation, dose heterogeneity, ballistics, are also means of optimizing the protection of normal tissues. Non-coplanarity and tracking of moving targets allow dosimetric improvement in some clinical settings. Automatic planning could also improve normal tissue protection. Adaptive SBRT, with new image guided radiotherapy modalities such as MRI, could further reduce the risk of toxicity. |
| Databáze: | OpenAIRE |
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