Modelling far field pacing for terminating spiral waves pinned to ischaemic heterogeneities in cardiac tissue
| Autor: | Stefan Luther, Edda Boccia, Ulrich Parlitz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Normalization property
vulnerable window Materials science Myocardial ischemia Defibrillation General Mathematics medicine.medical_treatment Quantitative Biology::Tissues and Organs Myocardial Ischemia General Physics and Astronomy Action Potentials Near and far field anisotropy 030204 cardiovascular system & hematology 01 natural sciences 03 medical and health sciences 0302 clinical medicine Heart Conduction System 0103 physical sciences medicine Animals Humans Computer Simulation 010306 general physics Anisotropy Spiral General Engineering Cardiac Pacing Artificial Models Cardiovascular Arrhythmias Cardiac Mechanics Articles defibrillation 3. Good health virtual electrodes Therapy Computer-Assisted excitable media cardiac dynamics Electrical conduction system of the heart Research Article |
| Zdroj: | Philosophical transactions. Series A, Mathematical, physical, and engineering sciences |
| ISSN: | 1471-2962 1364-503X |
| Popis: | In cardiac tissue, electrical spiral waves pinned to a heterogeneity can be unpinned (and eventually terminated) using electric far field pulses and recruiting the heterogeneity as a virtual electrode. While for isotropic media the process of unpinning is much better understood, the case of an anisotropic substrate with different conductivities in different directions still needs intensive investigation. To study the impact of anisotropy on the unpinning process, we present numerical simulations based on the bidomain formulation of the phase I of the Luo and Rudy action potential model modified due to the occurrence of acute myocardial ischaemia. Simulating a rotating spiral wave pinned to an ischaemic heterogeneity, we compare the success of sequences of far field pulses in the isotropic and the anisotropic case for spirals still in transient or in steady rotation states. Our results clearly indicate that the range of pacing parameters resulting in successful termination of pinned spiral waves is larger in anisotropic tissue than in an isotropic medium. This article is part of the themed issue ‘Mathematical methods in medicine: neuroscience, cardiology and pathology’. |
| Databáze: | OpenAIRE |
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