Effects of N-3 PUFAs Supplementation on Insulin Resistance and Inflammatory Biomarkers in Hemodialysis Patients

Autor: G. Perunicic, Z. Rasic-Milutinovic, S. Sobajic, D. Ristic, I. Djuric, Z. Gluvic, S. Pljesa
Rok vydání: 2007
Předmět:
Male
030309 nutrition & dietetics
medicine.medical_treatment
Yugoslavia
030204 cardiovascular system & hematology
Critical Care and Intensive Care Medicine
0302 clinical medicine
insulin resistance
Insulin
chemistry.chemical_classification
0303 health sciences
education.field_of_study
end-stage renal disease
food and beverages
General Medicine
Middle Aged
3. Good health
C-Reactive Protein
Treatment Outcome
Nephrology
lipids (amino acids
peptides
and proteins)
Female
Hemodialysis
Inflammation Mediators
medicine.symptom
Polyunsaturated fatty acid
Adult
medicine.medical_specialty
Population
n-3 PUFAs
Inflammation
End stage renal disease
03 medical and health sciences
Insulin resistance
Renal Dialysis
Fatty Acids
Omega-6
Internal medicine
Fatty Acids
Omega-3
medicine
Humans
inflammatory marker TNF-alpha
education
Pancreatic hormone
Aged
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
Erythrocyte Membrane
n-6 PUFAs
medicine.disease
Cross-Sectional Studies
Endocrinology
chemistry
Dietary Supplements
Ferritins
Multivariate Analysis
Linear Models
Kidney Failure
Chronic
Insulin Resistance
business
Follow-Up Studies
Zdroj: Reproductive Toxicology
ISSN: 1525-6049
0886-022X
DOI: 10.1080/08860220601184092
Popis: Aims/Hypothesis. It was suggested that polyunsaturated n-3 fatty acids (n-3 PUFAs) could improve insulin sensitivity and have an anti-inflammatory effects in overall population. This study investigates a possible effect of n-3 PUFAs supplementation on the insulin sensitivity and some inflammatory markers; hence, patients with chronic renal failure (CRF) on maintenance hemodialysis (MHD) are presented with insulin resistance. Methods. This study explored the ratio between red blood cells (RBC) phospholipid long chain fatty acids (LC FAs) and components of metabolic syndrome (MeS) in 35 patients (mean age 54.50 +/- 11.99 years) with CRF on MHD. Furthermore, the effects of omega-3 FA eight-week's supplementation (EPA+DHA, 2.4g/d) on the MeS features and inflammatory markers TNF-alpha, IL 6, and hsCRP were examined. Results. Supplementation increased EPA and DHA levels in RBCs (p = 0.009 for EPA and p = 0.002 for DHA). Total n-6 PUFAs: n-3 PUFAs ratio tended to be lower after supplementation (p = 0.31), but not significantly. Data revealed a significant decrease of saturated FAs (SFA) (P = 0.01) as well as total SFA: n-3 PUFAs ratio during the treatment (P = 0.04). The values of serum insulin and calculated IR index-IR HOMA were reduced after supplementation (p = 0.001 for both). There was a significant decrease in the levels of all inflammatory markers (p = 0.01 for TNF alpha, p = 0.001 for IL 6, p = 0.001 for hsCRP, and p = 0.01 for ferritin). In multivariate regression analysis, only the changes in n-6 PUFAs: n-3 PUFAs ratio independently contributed to 40% of the variance in IR HOMA. The impact of changes in PUFAs level in RBCs membrane phospholipid fatty acids on inflammation markers was also registered. The changes in n-6: n-3 PUFAs ratio independently contributed to 19% of the variance in TNF alpha. Conclusion. It was concluded that the EPA and DHA moderate dose administration in the patients with CRF on MHD had a beneficial effect on insulin resistance decrease. The anti-inflammatory effects of the supplemented PUFAs were also presented.
Databáze: OpenAIRE
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