Scintigraphic features of chronic sialadenitis and Sjögrenʼs syndrome
| Autor: | J E Goin, G A Hermann, F B Vivino |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Systemic disease Pathology medicine.medical_specialty Biopsy Population Scintigraphy Gastroenterology Salivary Glands Sialadenitis Diagnosis Differential stomatognathic system Reference Values Immunopathology Internal medicine Humans Medicine Tissue Distribution Radiology Nuclear Medicine and imaging Radionuclide Imaging education Aged Sodium Pertechnetate Tc 99m Aged 80 and over Autoimmune disease education.field_of_study medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease stomatognathic diseases Sjogren's Syndrome Chronic Disease Female Radiopharmaceuticals Abnormality business |
| Zdroj: | Nuclear Medicine Communications. 20:1123-1132 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/00006231-199912000-00004 |
| Popis: | An abnormal salivary scintigram is an accepted objective criterion in the diagnosis of primary and secondary Sjögren's syndrome, an immune-mediated disorder characterized by xerostomia and kerato-conjunctivitis sicca. However, chronic sialadenitis constitutes a major differential diagnostic consideration in the xerostomic population. We investigated 39 cases of biopsy-confirmed chronic sialadenitis and 152 individuals with first- or second-degree Sjögren's syndrome, according to international classification criteria. We analysed scintigraphic defects in terms of glands per patient, distribution patterns, kinetics and severity. Relative to Sjögren's syndrome, chronic sialadenitis showed significantly fewer defective glands per patient, less frequent dual parotid-submandibular defects, fewer combined deficits of uptake and discharge, and milder uptake failure. No statistically significant differences were found in the frequency of single gland abnormality, predilection for submandibular involvement, and respective proportions of uptake-only and discharge-only defects. Unevaluable discharge due to low uptake, although comprising only 34% of test-positive cases, appeared to be a highly specific but insensitive scintigraphic marker for Sjögren's syndrome. In non-irradiated xerostomic populations, scintigraphy provides specific, albeit limited, diagnostic information. The procedure's ability to distinguish uptake failure from secretory failure may be a useful asset in guiding clinical management strategies and estimating outcomes. |
| Databáze: | OpenAIRE |
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