Targeting the neurokinin receptor 1 with aprepitant: a novel antipruritic strategy
| Autor: | Thomas A. Luger, Cord Sunderkötter, I. Herrgott, Dorothee Siepmann, Sonja Ständer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Dermatology/Psoriasis and Other Inflammatory Diseases Dermatology/Skin and Systemic Disease Morpholines Science Substance P Dermatology Pharmacology chemistry.chemical_compound Mediator medicine Humans Serlopitant skin and connective tissue diseases Receptor Antipruritic Aprepitant Aged Aged 80 and over Multidisciplinary integumentary system business.industry Pruritus Antagonist Atopic dermatitis Middle Aged Receptors Neurokinin-1 medicine.disease Treatment Outcome chemistry Chronic Disease Medicine Female business Dermatology/Atopic Dermatitis and Other Forms of Eczema Research Article medicine.drug |
| Zdroj: | PLoS ONE, Vol 5, Iss 6, p e10968 (2010) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | BackgroundChronic pruritus is a global clinical problem with a high impact on the quality of life and lack of specific therapies. It is an excruciating and frequent symptom of e.g. uncurable renal, liver and skin diseases which often does not respond to conventional treatment with e.g. antihistamines. Therefore antipruritic therapies which target physiological mechanisms of pruritus need to be developed. Substance P (SP) is a major mediator of pruritus. As it binds to the neurokinin receptor 1 (NKR1), we evaluated if the application of a NKR1 antagonist would significantly decrease chronic pruritus.Methods and findingsTwenty hitherto untreatable patients with chronic pruritus (12 female, 8 male; mean age, 66.7 years) were treated with the NKR1 antagonist aprepitant 80 mg for one week. 16 of 20 patients (80%) experienced a considerable reduction of itch intensity, as assessed by the visual analog scale (VAS, range 0 to 10). Considering all patients, the mean value of pruritus intensity was significantly reduced from 8.4 VAS points (SD +/-1.7) before treatment to 4.9 VAS points (SD +/-3.2) (pConclusionsThe high response rate in patients with therapy refractory pruritus suggests that the NKR1 antagonist aprepitant may indeed exhibit antipruritic effects and may present a novel, effective treatment strategy based on pathophysiology of chronic pruritus. The results are promising enough to warrant confirming the efficacy of NKR1 antagonists in a randomized, controlled clinical trial. |
| Databáze: | OpenAIRE |
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