Favorable function of Ectonucleoside triphosphate diphosphohydrolase 1 high expression in thyroid carcinoma

Autor:	Yun-Hua Zhu, Cheng Xiang, Jun-Hua Luo
Rok vydání:	2021
Předmět:	Male medicine.medical_specialty Biology QH426-470 Thyroid carcinoma chemistry.chemical_compound ENTPD1 Antigens CD Internal medicine Databases Genetic medicine Genetics Missense mutation Humans Thyroid Neoplasms Gene High expression Fatty acid metabolism Research Apyrase Age Factors General Medicine Methylation DNA Methylation Prognosis Phenotype Survival Analysis Gene Expression Regulation Neoplastic Endocrinology chemistry Ectonucleoside Triphosphate Diphosphohydrolase 1 Metabolic pathway Immunohistochemistry Female Metabolic Networks and Pathways
Zdroj:	Hereditas, Vol 158, Iss 1, Pp 1-11 (2021) Hereditas
ISSN:	1601-5223
Popis:	Background Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) has been proved to play a vital role in human cancers. Nevertheless, the exact role of ENTPD1 in thyroid carcinoma (THCA) remained unclear. This study aimed to evaluate its prognostic value and reveal the potential regulatory mechanism in THCA. Results (1) Higher expression of ENTPD1 was found in THCA tissue compared with normal tissue (all P P P P P P P Conclusions ENTPD1 was highly expressed in THCA, and ENTPD1 high expression contributed to the prognosis of THCA patients. The present study inferred that ENTPD1 might serve as a metabolism-related gene and play a critical role in THCA through regulating metabolic pathways.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246324c83438de78339c24a72410a2c7 https://pubmed.ncbi.nlm.nih.gov/34465393 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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