Are Bilirubin and Plasma Lipid Profiles of Premature Infants Dependent on the Lipid Emulsion Infused?
| Autor: | Jacqueline Sulkes, Daniella Harell, Nora Naor, Ronit Pakula, Lea Sirota, Shmuel Davidson, Moshe Rubin, Dov Lichtenberg, Asher Moser |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Fat Emulsions Intravenous medicine.medical_specialty Bilirubin Levocarnitine chemistry.chemical_compound Carnitine Internal medicine medicine Humans Phospholipids Triglycerides Dose-Response Relationship Drug Triglyceride business.industry Hypertriglyceridemia Infant Newborn Gastroenterology medicine.disease Lipids Dose–response relationship Cholesterol Parenteral nutrition Endocrinology chemistry Biochemistry Pediatrics Perinatology and Child Health Lipid emulsion Female Parenteral Nutrition Total business Infant Premature medicine.drug |
| Zdroj: | Journal of Pediatric Gastroenterology and Nutrition. 21:25-30 |
| ISSN: | 0277-2116 |
| Popis: | The effect of a lipid emulsion containing long-chain triglycerides (LCT) and supplemented with L-carnitine on plasma lipids and bilirubin in premature neonates on total parenteral nutrition was compared to that of lipid emulsions containing either LCT or a mixture of LCT and medium-chain triglycerides (MCT). In a double-blind randomized study 49 premature neonates received one of the three fat emulsions, given intravenously, over 16-20 h daily for 6 days. Plasma carnitine levels increased significantly in the supplemented group only; the addition of carnitine did not seem to affect any of the parameters studied. Mean plasma triglycerides rose by 193 and 199% in the carnitine-supplemented and the LCT groups, respectively, and by 314% in the MCT/LCT group. On the sixth day of the study free fatty acids were significantly higher in the MCT/LCT group than in the other two groups. Plasma phospholipids and free cholesterol increased (p < 0.05) progressively in all groups and were correlated (r = 0.74, p < 0.001). At the end of the 6-day study all groups showed a similar decline in free and total bilirubin levels despite the significant increase in plasma lipids and free fatty acids resulting from the stepwise increase in lipid load. No correlation was found between free fatty acids and free bilirubin. Since hyperbilirubinemia and hypertriglyceridemia appear to be clinically independent factors, the infusion of lipids should not be withheld from jaundiced infants on total parenteral nutrition. |
| Databáze: | OpenAIRE |
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