Eudragit RL100 based microspheres for ocular administration of azelastine hydrochloride
| Autor: | Ujwala A Shinde, Kavita Singh, Jaykumar N Shete, Hema A. Nair |
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| Rok vydání: | 2012 |
| Předmět: |
Materials science
Azelastine Hydrochloride Scanning electron microscope Pharmaceutical Science Administration Ophthalmic Bioengineering Microsphere Rats Sprague-Dawley Delayed-Action Preparations Colloid and Surface Chemistry Differential scanning calorimetry Polymethacrylic Acids Polymer ratio Anti-Allergic Agents Zeta potential Animals Particle Size Physical and Theoretical Chemistry Conjunctivitis Allergic Chromatography Organic Chemistry Microspheres Rats Phthalazines Female Particle size |
| Zdroj: | Journal of Microencapsulation. 29:511-519 |
| ISSN: | 1464-5246 0265-2048 |
| DOI: | 10.3109/02652048.2012.665088 |
| Popis: | In the present study, potential of polymeric microspheres for treatment of allergic conjunctivitis was investigated. Azelastine hydrochloride loaded Eudragit RL100 microspheres were prepared by solvent evaporation technique. The change in drug-polymer ratio on the particle size, zeta potential, entrapment efficiency and in vitro drug release was investigated. As Eudragit concentration ranged from 40 to 80 mg/ml the size range obtained was 4.18-7.36 µm with positive zeta potential. With the increase in drug polymer ratio, the entrapment efficiency was increased with maximum 14.56%. In vitro release studies demonstrated prolonged release of the drug over the period of 6 hr. Scanning electron micrographs showed that microspheres were spherical with distinct solid dense structure. Fourier transform infrared and differential scanning calorimetry studies concluded slight change in peak intensities of drug in microspheres. In vivo studies in rat model indicated that reduction in eosinophil count number was more pronounced in azelastine hydrochloride microspheres than marketed formulation, Azelast®. |
| Databáze: | OpenAIRE |
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