Efficacy of different commercial and new inactivated vaccines against ovine enzootic abortion
Autor: | J.N. García de la Fuente, Jesús Salinas, César B. Gutiérrez-Martín, E. F. Rodríguez-Ferri, N. Ortega, O.R González, M.L. del Río |
---|---|
Rok vydání: | 2004 |
Předmět: |
Male
Sheep Diseases Chlamydiae Enzyme-Linked Immunosorbent Assay Enzootic abortion Microbiology Body Temperature Serology Random Allocation Pregnancy Animals Chlamydiaceae Chlamydophila Infections Sheep General Veterinary biology Chlamydophila Body Weight Vaccination Domestic sheep reproduction General Medicine Abortion Veterinary biology.organism_classification Antibodies Bacterial Virology Chlamydophila abortus Antibody response Animals Newborn Vaccines Inactivated Chlamydiales Bacterial Vaccines Female |
Zdroj: | Veterinary Microbiology. 100:65-76 |
ISSN: | 0378-1135 |
DOI: | 10.1016/j.vetmic.2004.01.015 |
Popis: | The protective efficacy of two inactivated commercial (A, B) and two new inactivated vaccines (M7, QS) against ovine enzootic abortion was determined in two separate experiments in sheep. Vaccine A contained chlamydiae propagated in chicken embryos, adjuvated with Marcol 82, and vaccine B contained chlamydiae cultured in cell monolayers, adjuvated with aluminium hydroxide. For the preparation of the experimental vaccines, Chlamydophila abortus AB7 strain was cultured in McCoy cells and adjuvated with QS-21 (QS) or Montanide ISA 773 (M7). The ewes were vaccinated twice subcutaneously and challenged at 90 days of gestation. Protection was evaluated by clinical, bacteriological and serological examinations, and compared to two control groups: one of infected but not vaccinated ewes, and another of vaccinated but not infected ewes. The experimental vaccines induced considerably better protection than the two commercial ones. The new vaccine M7 especially showed no abortions, a good antibody response, the highest newborn lamb weights and the lowest level of C. abortus shedding at lambing. |
Databáze: | OpenAIRE |
Externí odkaz: |