Gene Expression of Perform and Granzyme A in the Liver in Chronic Hepatitis C: Comparison with Peripheral Blood Mononuclear Cells
| Autor: | Shiro Fukumoto, Sino Sakai, Makoto Watanabe, Aktaruzzarman Chowdhury, Shuji Akagi, Shunji Ishihara, Ryo Fukuda, Xuan-Thanh Nguyen, Alejandlo Tokuda, Norihisa Ishimura |
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| Rok vydání: | 1995 |
| Předmět: |
Pore Forming Cytotoxic Proteins
Hepatitis C virus Molecular Sequence Data Immunology Gene Expression medicine.disease_cause Polymerase Chain Reaction Microbiology Granzymes Virology medicine Humans Cytotoxic T cell RNA Messenger Membrane Glycoproteins Base Sequence biology medicine.diagnostic_test Perforin Serine Endopeptidases hemic and immune systems Hepatitis C medicine.disease Liver Granzyme Liver biopsy Leukocytes Mononuclear Granzyme A biology.protein Viral hepatitis |
| Zdroj: | Microbiology and Immunology. 39:873-877 |
| ISSN: | 0385-5600 |
| DOI: | 10.1111/j.1348-0421.1995.tb03284.x |
| Popis: | Perforin and granzyme A are the major effectors of cytotoxic T cells in cell-mediated cytotoxicity. However, there has been no report on these effectors in chronic viral hepatitis. In the present study, the expression of perforin and granzyme A mRNA was investigated by the reverse transcription polymerase chain reaction method using liver biopsy specimens and peripheral mononuclear cells (PBMC) from 21 patients with chronic hepatitis C and 5 control cases. Perforin mRNA was detected only in the liver of chronic hepatitis patients but not in the control livers. Conversely, perforin mRNA was not expressed in PBMC of the patients with chronic hepatitis (P |
| Databáze: | OpenAIRE |
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