Lack of association between four SNPs in the SLC22A3-LPAL2-LPA gene cluster and coronary artery disease in a Chinese Han population: a case control study
| Autor: | Min Xia, Wenjun Ma, Ping Ouyang, Dan Li, Changjiang Hong, Xinrui Li, Yan Yang, Xiang Feng, Xiaoyu Zuo, Min Wang, Xiaofei Lv, Yuan Zhang, Shaoqi Rao, Fengqiong Liu, Jian Qiu, Dongfang Su, Wenhua Ling, Dan Feng, Honghui Guo |
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| Jazyk: | angličtina |
| Předmět: |
Male
China Organic Cation Transport Proteins Endocrinology Diabetes and Metabolism Population Clinical Biochemistry SNP Single-nucleotide polymorphism Coronary Artery Disease Polymorphism Single Nucleotide Endocrinology Lp(a) Gene cluster Humans Genetic Predisposition to Disease CAD SLC22A3-LPAL2-LPA cardiovascular diseases Allele education lcsh:RC620-627 Genetic Association Studies Aged Genetics Biochemistry medical education.field_of_study biology Research Biochemistry (medical) Haplotype Case-control study Lipoprotein(a) Middle Aged Association study lcsh:Nutritional diseases. Deficiency diseases Haplotypes Case-Control Studies Multigene Family biology.protein Female Apolipoprotein A-II |
| Zdroj: | Lipids in Health and Disease Lipids in Health and Disease, Vol 11, Iss 1, p 128 (2012) |
| ISSN: | 1476-511X 1075-5578 |
| DOI: | 10.1186/1476-511x-11-128 |
| Popis: | Background Lipoprotein (a) (Lp [a]) is known being correlated with coronary artery disease (CAD). The SLC22A3-LPAL2-LPA gene cluster, relating with modulating the level of plasma Lp (a), has recently been reported to be associated with CAD in Caucasians. The purpose of this study was to verify whether this finding can be expanded to the Chinese Han population. Methods and Results Using a Chinese Han sample, which consisted of 1012 well-characterized CAD patients and 889 healthy controls, we tested the associations of four SNPs (rs2048327, rs3127599, rs7767084 and rs10755578) in the SLC22A3-LPAL2-LPA gene cluster, and their inferred haplotypes with the risk of CAD. Allelic, genotypic and haplotype association analyses all showed that the gene cluster was not associated with CAD in this Chinese Han sample. Conclusions We for the first time explored the association of the four SNPs in the SLC22A3-LPAL2-LPA gene cluster with CAD in a large Chinese Han sample. Nevertheless, this study did not reveal any significant evidence of this gene cluster to increase the risk of CAD in this population. |
| Databáze: | OpenAIRE |
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