Update on optimal use of omalizumab in management of asthma
| Autor: | Maria Teresa Busceti, Alessandro Vatrella, Serafino A. Marsico, Luca Gallelli, Rosa Daniela Grembiale, Girolamo Pelaia, Rosario Maselli, Pasquale Romeo, Teresa Renda |
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| Rok vydání: | 2011 |
| Předmět: |
severe asthma
Pulmonary and Respiratory Medicine Drug biology business.industry media_common.quotation_subject anti-IgE omalizumab Review Omalizumab Immunoglobulin E medicine.disease Immunology Monoclonal biology.protein Immunology and Allergy Medicine Respiratory system Antibody Receptor business media_common medicine.drug Asthma |
| Zdroj: | Journal of Asthma and Allergy |
| ISSN: | 1178-6965 |
| DOI: | 10.2147/jaa.s14520 |
| Popis: | Omalizumab is a humanized monoclonal anti-IgE antibody recently approved for the treatment of severe allergic asthma. This drug inhibits allergic responses by binding to serum IgE, thus preventing interaction with cellular IgE receptors. Omalizumab is also capable of downregulating the expression of high affinity IgE receptors on inflammatory cells, as well as the numbers of eosinophils in both blood and induced sputum. The clinical effects of omalizumab include improvements in respiratory symptoms and quality of life, paralleled by a reduction of asthma exacerbations, emergency room visits, and use of systemic corticosteroids and rescue bronchodilators. Omalizumab is relatively well-tolerated, and only rarely induces anaphylactic reactions. Therefore, this drug represents a valid option as add-on therapy for patients with severe persistent allergic asthma inadequately controlled by high doses of standard inhaled treatments. |
| Databáze: | OpenAIRE |
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