| Autor: |
Kendra S. Carmon, Qingyun Liu, Zhiqiang An, Wei Xiong, Sukhen C. Ghosh, Ali Azhdarinia, Xing Gong |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1535-7163.22507449.v1 |
| Popis: |
Supplementary Fig. S1- Coomassie gel of anti-LGR5 mAb and anti-LGR5 ADCs. Supplementary Fig. S2- Confocal image of HEK293T cells with stable over-expression of hLGR4. Supplementary Fig. S3- Anti-LGR5 ADC binding assay and cytotoxicity of free MMAE. Supplementary Fig. S4- Anti-LGR5 mAb crossreactivity with mouse LGR5 and images of intestinal organoids treated with anti-LGR5 ADC or free MMAE. Supplementary Fig. S5- Representative images of LoVo xenograft tumors in mice from each treatment cohort and graph of average body weight. Supplementary Fig. S6- H&E staining of intestinal tissue sections. Supplementary Fig. S7. Images of Lovo xenograft tumor recurrence and weight. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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