The Implication of AMPA Receptor in Synaptic Plasticity Impairment and Intellectual Disability in Fragile X Syndrome
| Autor: | Dan Liu, Shawn M. McClintock, Ya Die Xiang, Xiang Yu Li, Yan Zeng, Gui Rong Cheng |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
congenital hereditary and neonatal diseases and abnormalities Physiology AMPA receptor Biology Neurotransmission Synapse 03 medical and health sciences 0302 clinical medicine Intellectual Disability Intellectual disability medicine Animals Humans Receptors AMPA Neuronal Plasticity Glutamate receptor General Medicine medicine.disease Fragile X syndrome Protein Transport 030104 developmental biology nervous system Fragile X Syndrome Mutation Synaptic plasticity Autism Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Physiological Research. :715-727 |
| ISSN: | 1802-9973 0862-8408 |
| DOI: | 10.33549/physiolres.933473 |
| Popis: | Fragile X syndrome (FXS) is the most frequently inherited form of intellectual disability and prevalent single-gene cause of autism. A priority of FXS research is to determine the molecular mechanisms underlying the cognitive and social functioning impairments in humans and the FXS mouse model. Glutamate ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors (AMPARs) mediate a majority of fast excitatory neurotransmission in the central nervous system and are critically important for nearly all aspects of brain function, including neuronal development, synaptic plasticity, and learning and memory. Both preclinical and clinical studies have indicated that expression, trafficking, and functions of AMPARs are altered and result in altered synapse development and plasticity, cognitive impairment, and poor mental health in FXS. In this review, we discuss the contribution of AMPARs to disorders of FXS by highlighting recent research advances with a specific focus on change in AMPARs expression, trafficking, and dependent synaptic plasticity. Since changes in synaptic strength underlie the basis of learning, development, and disease, we suggest that the current knowledge base of AMPARs has reached a unique point to permit a comprehensive re-evaluation of their roles in FXS. |
| Databáze: | OpenAIRE |
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