Effect of a novel anti-rheumatic drug, TA-383, on type II collagen-induced arthritis--suppressive effect of TA-383 on interleukin 6 production
| Autor: | Tetsuya Tosa, Makoto Ueno, Isao Takata, Osamu Furukawa, Takanori Murakami, Takahisa Sugita |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Immunology Type II collagen Arthritis Recombinant Interleukin In Vitro Techniques Autoimmune Diseases Mice Internal medicine medicine Animals Receptor Interleukin 6 Pharmacology biology business.industry Interleukin-6 Anti-Inflammatory Agents Non-Steroidal Synovial Membrane Imidazoles Fibroblasts medicine.disease In vitro Endocrinology Cytokine Mechanism of action Mice Inbred DBA biology.protein Collagen medicine.symptom business |
| Zdroj: | International journal of immunopharmacology. 15(4) |
| ISSN: | 0192-0561 |
| Popis: | We have evaluated the effect of a novel anti-rheumatic drug, cis -2-(4-chlorophenyl)-4, 5-diphenyl-2-imidazoline hydrochloride (TA-383), on type II collagen (CII)-induced arthritis in DBA/1J mice. Treatment with TA-383 (0.4 mg/kg/day) from the day of immunization with CII strongly suppressed the arthritic responses. Increased serum interleukin 6 (IL-6) level was lowered in parallel with the effect. Effect of TA-383 on IL-6 production was examined in vitro . TA-383 inhibited the production of IL-6 by murine synovial fibroblasts stimulated with recombinant interleukin 1 (IL-1) β in a dose-dependent manner (0.1–10 μM). Neither the general protein synthesis nor the expression of type I IL-1 receptor was affected by TA-383. The results show that TA-383 possesses an inhibitory activity on IL-6 generation and suggest that the effect may partly contribute to the anti-arthritic effect of TA-383. |
| Databáze: | OpenAIRE |
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