Hemodynamic Impact of Transcatheter Aortic Valve Deployment Configuration
| Autor: | Eric Sirois, Wei Sun, Joe Calderan, Kewei Li, Lisong Ai |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Transcatheter aortic business.industry Aortic root Biomedical Engineering Medicine (miscellaneous) Treatment options Hemodynamics Multislice computed tomography medicine.disease Frontiers Abstracts Calcium deposition Cross section (geometry) Stenosis Internal medicine Cardiology Medicine business Biomedical engineering |
| Zdroj: | Journal of medical devices. 7(4) |
| ISSN: | 1932-6181 |
| Popis: | Transcatheter aortic valve (TAV) replacement holds promise for a large number of patients who otherwise have limited or no treatment options. However, it also poses various challenges, due to its unique disease treatment mechanism. Successful TAV deployment and function are heavily reliant on the tissue-stent interaction [1,2]. For patients with aortic stenosis, heavy calcium deposition on the valve leaflets and the aortic root can also cause distortion of TAV geometries, resulting in a valve of an elliptical shape [3–5] instead of a nominal circular shape. In a recent study by Schultz et al. [5], the geometry and apposition of the TAV after implantation in 30 patients with aortic stenosis were evaluated using multislice computed tomography. The results indicated that none of the TAV frames reached exactly nominal designed dimensions. The difference between the orthogonal smallest and largest diameters of TAV cross section at the ventricular end was 4.4 mm, which was clearly an asymmetric elliptical shape [5]. In this study, we sought to develop computational models of valve hemodynamics under clinically relevant deployment scenarios. |
| Databáze: | OpenAIRE |
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