Fusion of HMGA2 to COG5 in uterine leiomyoma
| Autor: | Gopalrao V.N. Velagaleti, Hongying Zhang, Fabiola Medeiros, Michele R. Erickson-Johnson, Nawar Hakim, Vijay S. Tonk, Andre M. Oliveira, Xiaoke Wang |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Gene isoform Cancer Research Molecular Sequence Data Biology Fusion gene Genetics medicine Humans Molecular Biology In Situ Hybridization Fluorescence Actin Gene Rearrangement Uterine leiomyoma Base Sequence Leiomyoma medicine.diagnostic_test Reverse Transcriptase Polymerase Chain Reaction HMGA2 Protein Gene Amplification Fusion protein Molecular biology Adaptor Proteins Vesicular Transport Uterine Neoplasms Smooth Muscle Tumor Female Desmin Gene Fusion Fluorescence in situ hybridization |
| Zdroj: | Cancer Genetics and Cytogenetics. 202:11-16 |
| ISSN: | 0165-4608 |
| Popis: | Uterine leiomyomas are smooth muscle tumors most commonly seen in middle-aged women. Approximately 10% of these tumors contain rearrangements of the chromatin-remodeling gene HMGA2 at the chromosome band 12q14.3. Herein, we report on a uterine leiomyoma with a novel HMGA2 fusion gene. A 44-year-old woman presented with a 20-cm mass uterine leiomyoma. From a histological standpoint, the tumor exhibited extensive hyalinization, very low mitotic activity ( |
| Databáze: | OpenAIRE |
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