Association of apolipoprotein E polymorphisms with normal tension glaucoma in a Chinese population
| Autor: | Baojian Fan, Chiu Lam Ds, Lam Cy, Yung Tham Cc, Chi Pui Pang, Ping Fan Ds, Wang Dy, Tam Po, Leung Dy |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Apolipoprotein E
Adult Male medicine.medical_specialty Intraocular pressure genetic structures Adolescent Genotype Apolipoprotein E4 Glaucoma Polymerase Chain Reaction symbols.namesake Apolipoproteins E Asian People Polymorphism (computer science) Risk Factors Normal tension glaucoma Internal medicine medicine Humans Allele Child Fisher's exact test Intraocular Pressure Aged Aged 80 and over Polymorphism Genetic business.industry Odds ratio Middle Aged medicine.disease eye diseases Ophthalmology Endocrinology Phenotype symbols Hong Kong Female sense organs business Glaucoma Open-Angle |
| Zdroj: | Journal of glaucoma. 15(3) |
| ISSN: | 1057-0829 |
| Popis: | PURPOSE To evaluate the role of apolipoprotein E (APOE) polymorphisms in primary open angle glaucoma (POAG). METHODS A cohort of 400 unrelated Chinese POAG patients was examined, including 294 cases of high tension glaucoma (HTG) and 106 with normal tension glaucoma (NTG). Also studied were 300 unrelated Chinese control subjects. The genotypes of the APOE polymorphisms in exon 4 and in the promoter at positions -491, -427, and -219 were determined by polymerase chain reaction and restriction endonuclease analysis. Frequencies of the genotypes were compared between patients and controls by chi test or Fisher exact test. The association of APOE polymorphisms with POAG phenotypes including age at diagnosis, intraocular pressure (IOP) at diagnosis, highest IOP, cup-disc ratio, and visual field score was investigated by the Kruskal-Wallis test. RESULTS No significant difference was detected in the frequencies of APOE promoter polymorphisms between POAG patients and control subjects (P>0.0125). For the exon 4 polymorphism, when compared with control subjects, the frequency of epsilon 4 carriers was significantly lower in patients with NTG (P=0.008; odds ratio=0.36, 95% confidence interval=0.17, 0.79) but not in HTG (P=0.07). Compared with -219TT, the -219G carriers had a significant higher age at diagnosis (P=0.0046). No significant association was found between other APOE polymorphisms and POAG phenotypes (P>0.07). CONCLUSIONS Our findings suggest that the APOE epsilon 4 allele confers a protective effect against NTG, whereas the APOE promoter polymorphisms do not contribute to POAG risk. However, the APOE -219G carriers tended to have later-onset POAG. |
| Databáze: | OpenAIRE |
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