Plasma ammonia concentrations in extremely low birthweight infants in the first week after birth: secondary analysis from the ProVIDe randomized clinical trial
| Autor: | Roland S. Broadbent, Michael Hewson, Dianne Webster, Michael P. Meyer, Adrienne M Lynn, Jane E. Harding, Caroline A Crowther, Emma Glamuzina, Frank H. Bloomfield, Barbara E. Cormack, Bryony Ryder, Arun Nair, Yannan Jiang |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Gestational Age law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Interquartile range law Ammonia 030225 pediatrics Intensive care Secondary analysis Intensive Care Units Neonatal medicine Birth Weight Humans Hyperammonemia 030212 general & internal medicine Clinical Research Article Obstetrics business.industry Infant Newborn Gestational age Birth characteristics Postnatal age Treatment Outcome Infant Extremely Low Birth Weight Data Interpretation Statistical Pediatrics Perinatology and Child Health Intensive Care Neonatal Arterial blood Female business New Zealand |
| Zdroj: | Pediatric Research |
| ISSN: | 1530-0447 |
| Popis: | BackgroundLittle is known about normative ammonia concentrations in extremely low birthweight (ELBW) babies and whether these vary with birth characteristics. We aimed to determine ammonia concentrations in ELBW babies in the first week after birth and relationships with neonatal characteristics and protein intake.MethodsArterial blood samples for the measurement of plasma ammonia concentration were collected within 7 days of birth from ProVIDe trial participants in six New Zealand neonatal intensive care units.ResultsThree hundred and twenty-two babies were included. Median (range) gestational age was 25.7 (22.7–31.6) weeks. Median (interquartile range (IQR)) ammonia concentration was 102 (80–131) µg/dL. There were no statistically significant associations between ammonia concentrations and birthweight or sex. Ammonia concentrations were weakly correlated with mean total (Spearman’srs = 0.11,P = 0.047) and intravenous (rs = 0.13,P = 0.02) protein intake from birth, gestational age at birth (rs = −0.13,P = 0.02) and postnatal age (rs = −0.13,P = 0.02).ConclusionsPlasma ammonia concentrations in ELBW babies are similar to those of larger and more mature babies and only weakly correlated with protein intake. Currently, recommended thresholds for investigation of hyperammonaemia are appropriate for ELBW babies. Protein intake should not be limited by concerns about potential hyperammonaemia. |
| Databáze: | OpenAIRE |
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