Reduction of Severity of Recurrent Psychotic Episode by Sustained Treatment with Aripiprazole in a Schizophrenic Patient with Dopamine Supersensitivity: A Case Report
| Autor: | Naho Nonomura, Masaomi Iyo, Shigenori Tadokoro, Kenji Hashimoto, Nobuhisa Kanahara |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Psychosis Pediatrics Exacerbation medicine.drug_class Antipsychotic agents Atypical antipsychotic Case Report 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine stomatognathic system Dopamine Recurrence Dopamine receptor D2 Receptors medicine Pharmacology (medical) Disease exacerbation Psychiatry dopamine D2 business.industry medicine.disease 030227 psychiatry Psychiatry and Mental health Clinical research Schizophrenia Aripiprazole business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Clinical Psychopharmacology and Neuroscience |
| ISSN: | 2093-4327 1738-1088 |
| Popis: | Dopamine supersensitivity psychosis (DSP) is a type of acute exacerbation of recurrent psychosis caused by long-term treatment with antipsychotics in schizophrenic patients. Although DSP is exceedingly troublesome for clinicians, effective treatment has not yet been established. Based on clinical research and our animal study, we hypothesize that aripiprazole, an atypical antipsychotic, may reduce the exacerbation of recurrent psychotic episodes. We report the case of a 46-year-old female who suffered from schizophrenia with DSP. In this case, sustained treatment with a high dose of aripiprazole gradually reduced the severity of her recurrent psychotic episodes. In conclusion, sustained treatment with aripiprazole may reduce the exacerbation of recurrent psychotic episodes in schizophrenic patients with DSP, and may be an effective treatment of DSP. |
| Databáze: | OpenAIRE |
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