Structure-Based Design of HIV-1 Protease Inhibitors: Replacement of Two Amides and a 10.pi.-Aromatic System by a Fused Bis-tetrahydrofuran
| Autor: | J. C. Culberson, M. G. Axel, Arun K. Ghosh, Paula M.D. Fitzgerald, P. S. Anderson, Wayne J. Thompson, Joel R. Huff, S. P. Mckee |
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| Rok vydání: | 1994 |
| Předmět: |
Models
Molecular Stereochemistry Alkylation Crystallography X-Ray chemistry.chemical_compound HIV Protease HIV-1 protease Drug Discovery medicine Furans Saquinavir Tetrahydrofuran chemistry.chemical_classification Molecular Structure biology Bicyclic molecule Chemistry Acetal Hydrogen Bonding HIV Protease Inhibitors Isoquinolines Enzyme Enzyme inhibitor Drug Design HIV-1 Quinolines biology.protein Molecular Medicine medicine.drug |
| Zdroj: | Journal of Medicinal Chemistry. 37:2506-2508 |
| ISSN: | 1520-4804 0022-2623 |
| Databáze: | OpenAIRE |
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