| Autor: |
Le, T. T. Yen, Geffard, Olivier, Geffard, Alain, Peijnenburg, Willie J. G. M. |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Critical Reviews in Environmental Science and Technology, 53(10), 1103-1125. Informa UK Limited |
| DOI: |
10.6084/m9.figshare.21175158.v2 |
| Popis: |
A general concept in risk assessment isthat a threshold of exposure exists abovewhich adverse effects are initiated. Toxicityis related to the target-site concentrationor the biologically active dose. Although itis often a huge challenge to measure thespecific dose metric of metal toxicity, sig-nificant progress has been obtained toapproach closer to the target-site concen-tration. Such developments are reviewedin the present study. In addition, a generalframework to simulate the subcellularmetal partitioning, which is supposed toaccount for the internal metal sequestra-tion, is developed and applied to variousmetals. The framework allows for delineat-ing mechanisms of internal metal sequestration. Moreover, the specificity in these mechanisms,which varies among metals, species, and exposure conditions, might explain the complicated rela-tionship between the internal concentration and metal toxicity. Attention should be paid to thedata requirements as the high number of unknown parameters might be accompanied by poten-tial uncertainties. In addition, future efforts should focus on linking the concentration of metals insensitive fractions and toxicological effects. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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