Long-lasting involuntary motor activity after spinal cord injury
| Autor: | T W Vitaz, D G L Terson de Paleville, Susan J. Harkema, Alexander V. Ovechkin, William B. McKay |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male 030506 rehabilitation medicine.medical_specialty Stimulation surface electromyography Neuroprotection Article Time Lesion Young Adult 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Motor control medicine Humans Muscle Skeletal Spinal Cord Injury Prospective cohort study Spinal cord injury Spinal Cord Injuries Aged Balance (ability) Aged 80 and over Dyskinesias business.industry Brain Motor Control Assessment General Medicine Middle Aged medicine.disease Spinal cord medicine.anatomical_structure Spinal Cord Neurology Muscle Spasticity Chronic Disease Reflex Female Spasticity Neurology (clinical) medicine.symptom 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | Spinal cord |
| ISSN: | 1476-5624 1362-4393 |
| Popis: | Study Design Prospective cohort study Objective This study was designed to neurophysiologically characterize spinal motor activity during recovery from spinal cord injury (SCI). Setting University of Louisville, Louisville, Kentucky, USA. Material Twenty five consecutive acute SCI admissions were recruited for this study. Methods The American Spinal Injury Association Impairment Scale (AIS) was used to categorize injury level and severity at onset. Surface EMG recording, was carried out initially between the day of admission and 17 days post onset (6.0 ± 4.3, mean ± SD days). Follow-up recordings were performed for up to 9 months after injury. Initial AIS distribution was: 7 AIS-A; 3 AIS-B; 2 AIS-C; 13 AIS-D. Results Twelve subjects (48%) showed long-duration involuntary motor unit activation during relaxation. This activity was seen on initial examination in nine and on follow-up by three months post-injury in three others. It was seen in muscles innervated from the injury zone in 11 and caudal to the lesion in 9 subjects. This activity was independent of the presence or absence of tendon reflexes and the ability to volitionally suppress plantar stimulation elicited reflex withdrawal. Conclusions The form of involuntary activity described here is the likely result of the altered balance of excitation and inhibition reaching spinal motor neurons due to the loss of inhibitory interneurons or their reduced activation by damaged supraspinal drive and the synaptic reorganization that follows SCI. As such, this activity may be useful for monitoring the effects of neuroprotective and restorative intervention strategies in persons with SCI. |
| Databáze: | OpenAIRE |
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